Stepwise or Linear Decrease in Penetrance of Type 1 Diabetes With Lower-Risk HLA Genotypes Over the Past 40 Years

OBJECTIVE: The objective of this study was to test if the proportion of new-onset diabetic subjects with the HLA-DR3/4-DQB1*0302 genotype is decreasing over time. RESEARCH DESIGN AND METHODS: We analyzed HLA class II genotype frequencies over time in two large populations with type 1 diabetes diagno...

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Hlavní autoři: Steck, Andrea K., Armstrong, Taylor K., Babu, Sunanda R., Eisenbarth, George S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046823/
https://ncbi.nlm.nih.gov/pubmed/21307077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1419
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