Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Potential for Rapid Screening

OBJECTIVE—People with the HLA genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (DR3/4-DQ8) are at the highest risk of developing type 1 diabetes. We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs). RESEARCH D...

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Detaylı Bibliyografya
Asıl Yazarlar: Barker, Jennifer M., Triolo, Taylor M., Aly, Theresa A., Baschal, Erin E., Babu, Sunanda R., Kretowski, Adam, Rewers, Marian J., Eisenbarth, George S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2008
Konular:
Genetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570414/
https://ncbi.nlm.nih.gov/pubmed/18694972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0605
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