Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells.
Retroviral vectors, designated handicapped, are described. These are genetically defective viruses that allow transfer of nonselectable genes under the transcriptional control of internal promoters. The basic handicapped vector (pHHAM) is derived from Harvey, Abelson, and Moloney murine retroviruses...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1987
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3031683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.8.2406 |
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