Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells.

Retroviral vectors, designated handicapped, are described. These are genetically defective viruses that allow transfer of nonselectable genes under the transcriptional control of internal promoters. The basic handicapped vector (pHHAM) is derived from Harvey, Abelson, and Moloney murine retroviruses...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hawley, R G, Covarrubias, L, Hawley, T, Mintz, B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3031683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.8.2406
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