Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer

INTRODUCTION: Mutational inactivation of the FBXW7/hCDC4 tumor suppressor gene (TSG) is common in many cancer types, but infrequent in breast cancers. This study investigates the presence and impact of FBXW7/hCDC4 promoter methylation in breast cancer. METHODS: FBXW7/hCDC4-β expression and promoter...

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Detalhes bibliográficos
Main Authors: Akhoondi, Shahab, Lindström, Linda, Widschwendter, Martin, Corcoran, Martin, Bergh, Jonas, Spruck, Charles, Grandér, Dan, Sangfelt, Olle
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046450/
https://ncbi.nlm.nih.gov/pubmed/21122106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2788
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