Optimization of the HA-1-specific T-cell receptor for gene therapy of hematologic malignancies

To broaden the applicability of adoptive T-cell therapy for the treatment of hematologic malignancies, we aim to start a clinical trial using HA-1-TCR transferred virus-specific T cells. TCRs directed against the minor histocompatibility antigen (MiHA) HA-1 are good candidates for TCR gene transfer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van Loenen, Marleen M., de Boer, Renate, Hagedoorn, Renate S., van Egmond, Esther H.M., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2011
Schlagworte:
Brief Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046283/
https://ncbi.nlm.nih.gov/pubmed/21109688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.025916
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