Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. Autoimmune side effects, however, remain a risk, emphasizing the relevance of a suicide mechanism allowing in vivo elimination of infused T cells. We investigated the use of human CD20 as suicide gene...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Griffioen, Marieke, van Egmond, Esther H.M., Kester, Michel G.D., Willemze, Roel, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2009
Schlagworte:
Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738728/
https://ncbi.nlm.nih.gov/pubmed/19734426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.001677
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