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Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4(+) T Cells

By gene transfer of HLA-class I restricted T-cell receptors (TCRs) (HLA-I-TCR) into CD8(+) as well as CD4(+) T-cells, both effector T-cells as well as helper T-cells can be generated. Since most HLA-I-TCRs function best in the presence of the CD8 co-receptor, the CD8αß molecule has to be co-transfer...

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書誌詳細
主要な著者: van Loenen, Marleen M., Hagedoorn, Renate S., de Boer, Renate, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667802/
https://ncbi.nlm.nih.gov/pubmed/23738014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065212
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