Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8(+) T cells in myeloid malignancies

BACKGROUND: We previously showed that vaccination with one dose of PR1 and WT1 peptides induces transient anti-leukemia immunity. We hypothesized that maintenance of a sustained anti-leukemia response may require frequent boost injections. DESIGN AND METHODS: Eight patients with myeloid malignancies...

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Autores principales: Rezvani, Katayoun, Yong, Agnes S.M., Mielke, Stephan, Jafarpour, Behnam, Savani, Bipin N., Le, Robert Q., Eniafe, Rhoda, Musse, Laura, Boss, Carol, Kurlander, Roger, Barrett, A. John
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046275/
https://ncbi.nlm.nih.gov/pubmed/21134985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.031674
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