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Ex vivo characterization of polyclonal memory CD8(+) T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia
Preferentially expressed antigen of melanoma (PRAME) is aberrantly expressed in hematologic malignancies and may be a useful target for immunotherapy in leukemia. To determine whether PRAME is naturally immunogenic, we studied CD8(+) T-cell responses to 4 HLA-A*0201–restricted PRAME-derived epitopes...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652370/ https://ncbi.nlm.nih.gov/pubmed/18988867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144071 |
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