Ex vivo characterization of polyclonal memory CD8(+) T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia

Preferentially expressed antigen of melanoma (PRAME) is aberrantly expressed in hematologic malignancies and may be a useful target for immunotherapy in leukemia. To determine whether PRAME is naturally immunogenic, we studied CD8(+) T-cell responses to 4 HLA-A*0201–restricted PRAME-derived epitopes...

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Autori principali: Rezvani, Katayoun, Yong, Agnes S. M., Tawab, Abdul, Jafarpour, Behnam, Eniafe, Rhoda, Mielke, Stephan, Savani, Bipin N., Keyvanfar, Keyvan, Li, Yixin, Kurlander, Roger, Barrett, A. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652370/
https://ncbi.nlm.nih.gov/pubmed/18988867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144071
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