Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy

PR1, an HLA-A*0201 epitope shared by proteinase-3 (PR3) and elastase (ELA2) proteins, is expressed in normal neutrophils and overexpressed in myeloid leukemias. PR1-specific T cells have been linked to graft-versus-leukemia (GVL) effect. We hypothesized that lymphopenia induced by chemo-radiotherapy...

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Main Authors: Rezvani, Katayoun, Yong, Agnes S. M., Mielke, Stephan, Savani, Bipin N., Jafarpour, Behnam, Eniafe, Rhoda, Le, Robert Quan, Musse, Laura, Boss, Carole, Childs, Richard, John Barrett, A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163946/
https://ncbi.nlm.nih.gov/pubmed/22198310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1187-z
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