High PR3 or ELA2 expression by CD34(+) cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide–driven graft-versus-leukemia effects

The primary granule proteins elastase (ELA2) and proteinase 3 (PR3) both contain the nonapeptide PR1, which can induce cytotoxic T lymphocyte (CTL) responses against chronic myeloid leukemia (CML) cells. To investigate whether eradication of CML after allogeneic stem cell transplantation (SCT) was i...

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Detalhes bibliográficos
Main Authors: Yong, Agnes S. M., Rezvani, Katayoun, Savani, Bipin N., Eniafe, Rhoda, Mielke, Stephan, Goldman, John M., Barrett, A. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924474/
https://ncbi.nlm.nih.gov/pubmed/17412886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-071738
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