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Predictions of Hot Spot Residues at Protein-Protein Interfaces Using Support Vector Machines

Protein-protein interactions are critically dependent on just a few ‘hot spot’ residues at the interface. Hot spots make a dominant contribution to the free energy of binding and they can disrupt the interaction if mutated to alanine. Here, we present HSPred, a support vector machine(SVM)-based meth...

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Detalles Bibliográficos
Main Authors: Lise, Stefano, Buchan, Daniel, Pontil, Massimiliano, Jones, David T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046169/
https://ncbi.nlm.nih.gov/pubmed/21386962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016774
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