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Prediction of hot spot residues at protein-protein interfaces by combining machine learning and energy-based methods
BACKGROUND: Alanine scanning mutagenesis is a powerful experimental methodology for investigating the structural and energetic characteristics of protein complexes. Individual amino-acids are systematically mutated to alanine and changes in free energy of binding (ΔΔG) measured. Several experiments...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777894/ https://ncbi.nlm.nih.gov/pubmed/19878545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-365 |
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