Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neurological...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Bauler, Timothy J., Kamiya, Nobuhiro, Lapinski, Philip E., Langewisch, Eric, Mishina, Yuji, Wilkinson, John E., Feng, Gen-Sheng, King, Philip D.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Limited 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046097/
https://ncbi.nlm.nih.gov/pubmed/21068439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.006130
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker