Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neurological...

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Autori principali: Bauler, Timothy J., Kamiya, Nobuhiro, Lapinski, Philip E., Langewisch, Eric, Mishina, Yuji, Wilkinson, John E., Feng, Gen-Sheng, King, Philip D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Limited 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046097/
https://ncbi.nlm.nih.gov/pubmed/21068439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.006130
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