Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neurological...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Bauler, Timothy J., Kamiya, Nobuhiro, Lapinski, Philip E., Langewisch, Eric, Mishina, Yuji, Wilkinson, John E., Feng, Gen-Sheng, King, Philip D.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Limited 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046097/
https://ncbi.nlm.nih.gov/pubmed/21068439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.006130
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars