Geometry of the antitumor drug ditercalinium bisintercalated into d(CpGpCpG)2 by 1H NMR.

Rigid 7H-pyrido[4,3-c]carbazole dimers, such as Ditercalinium, are DNA bisintercalators that display high DNA affinity and strong antitumor properties. This activity appears crucially dependent on the geometry of their complexes with DNA. Therefore, structures of the complexes formed by the self-com...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Delbarre, A, Delepierre, M, Garbay, C, Igolen, J, Le Pecq, J B, Roques, B P
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1987
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3470783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.8.2155
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