The Flv(r)-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

Resistance to flavivirus-induced disease in mice is conferred by the autosomal gene Flv, identified as 2′-5′ oligoadenylate synthetase 1b (Oas1b). Resistant mice express a full-length Oas1b protein while susceptible mice express the truncated Oas1btr. In this study, Oas1b was shown to be an inactive...

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Bibliographic Details
Main Authors: Elbahesh, H., Jha, B. K., Silverman, R. H., Scherbik, S. V., Brinton, M. A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046042/
https://ncbi.nlm.nih.gov/pubmed/21056894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.10.016
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