Mice Deficient in Oocyte-Specific Oligoadenylate Synthetase-Like Protein OAS1D Display Reduced Fertility

The double-stranded RNA (dsRNA)-induced interferon response is a defense mechanism against viral infection. Upon interferon activation by dsRNA, 2′,5′-oligoadenylate synthetase 1 (OAS1A) is induced; it binds dsRNA and converts ATP into 2′,5′-linked oligomers of adenosine (called 2-5A), which activat...

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Autori principali: Yan, Wei, Ma, Lang, Stein, Paula, Pangas, Stephanie A., Burns, Kathleen H., Bai, Yuchen, Schultz, Richard M., Matzuk, Martin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140637/
https://ncbi.nlm.nih.gov/pubmed/15899864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.11.4615-4624.2005
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