Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes

BACKGROUND: The mammalian OAS/RNASEL pathway plays an important role in antiviral host defense. A premature stop-codon within the murine Oas1b gene results in the increased susceptibility of mice to a number of flaviviruses, including West Nile virus (WNV). Mutations in either the OAS1 or RNASEL gen...

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Autori principali: Rios, Jonathan J, Perelygin, Andrey A, Long, Maureen T, Lear, Teri L, Zharkikh, Andrey A, Brinton, Margo A, Adelson, David L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048516/
https://ncbi.nlm.nih.gov/pubmed/17822564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-8-313
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