Design, Synthesis and Study of a Mycobactin-artemisinin Conjugate that has Selective and Potent Activity Against Tuberculosis and Malaria

Although the antimalarial agent, artemisinin itself is not active against tuberculosis, conjugation to a mycobacterial specific siderophore (microbial iron chelator) analog induces significant and selective anti-tuberculosis activity, including activity against MDR and XDR strains of Mtb. The conjug...

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Detalhes bibliográficos
Main Authors: Miller, Marvin J., Walz, Andrew J., Zhu, Helen, Wu, Chunrui, Moraski, Garrett, Möllmann, Ute, Tristani, Esther M., Crumbliss, Alvin L., Ferdig, Michael T., Checkley, Lisa, Edwards, Rachel L., Boshoff, Helena I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045749/
https://ncbi.nlm.nih.gov/pubmed/21275374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja109665t
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