Design, Synthesis and Study of a Mycobactin-artemisinin Conjugate that has Selective and Potent Activity Against Tuberculosis and Malaria

Although the antimalarial agent, artemisinin itself is not active against tuberculosis, conjugation to a mycobacterial specific siderophore (microbial iron chelator) analog induces significant and selective anti-tuberculosis activity, including activity against MDR and XDR strains of Mtb. The conjug...

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Bibliografiske detaljer
Main Authors: Miller, Marvin J., Walz, Andrew J., Zhu, Helen, Wu, Chunrui, Moraski, Garrett, Möllmann, Ute, Tristani, Esther M., Crumbliss, Alvin L., Ferdig, Michael T., Checkley, Lisa, Edwards, Rachel L., Boshoff, Helena I.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045749/
https://ncbi.nlm.nih.gov/pubmed/21275374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja109665t
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