The IGF Pathway Regulates ERα through a S6K1-Dependent Mechanism in Breast Cancer Cells

The IGF pathway stimulates malignant behavior of breast cancer cells. Herein we identify the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) axis as a critical component of IGF and estrogen receptor (ER)α cross talk. The insulin receptor substrate (IRS) adaptor molecules function downstream...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Becker, Marc A., Ibrahim, Yasir H., Cui, Xiaojiang, Lee, Adrian V., Yee, Douglas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2011
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045742/
https://ncbi.nlm.nih.gov/pubmed/21292829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0373
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