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The IGF Pathway Regulates ERα through a S6K1-Dependent Mechanism in Breast Cancer Cells
The IGF pathway stimulates malignant behavior of breast cancer cells. Herein we identify the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) axis as a critical component of IGF and estrogen receptor (ER)α cross talk. The insulin receptor substrate (IRS) adaptor molecules function downstream...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Endocrine Society
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3045742/ https://ncbi.nlm.nih.gov/pubmed/21292829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0373 |
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