GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

BACKGROUND: The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional target of hypoxia inducible factor 1 alp...

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Vydáno v:Breast Cancer Res
Hlavní autoři: De Francesco, Ernestina M., Sims, Andrew H., Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P., Clarke, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719673/
https://ncbi.nlm.nih.gov/pubmed/29212519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-017-0923-5
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