Rebamipide, a mucoprotective drug, inhibits NSAIDs-induced gastric mucosal injury: possible involvement of the downregulation of 15-hydroxyprostaglandin dehydrogenase

Prostaglandin E(2) plays an important role in the maintenance of gastric mucosal integrity. The level of biologically active prostaglandin E(2) in the tissue is regulated by the balanced expression of its synthetic enzymes, such as cyclooxygenase, and its catabolic enzyme, 15-hydroxyprostaglandin de...

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Hlavní autoři: Tanigawa, Tetsuya, Watanabe, Toshio, Ohkawa, Fumikazu, Nadatani, Yuji, Otani, Koji, Machida, Hirohisa, Okazaki, Hirotoshi, Yamagami, Hirokazu, Watanabe, Kenji, Tominaga, Kazunari, Fujiwara, Yasuhiro, Takeuchi, Koji, Arakawa, Tetsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: the Society for Free Radical Research Japan 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045688/
https://ncbi.nlm.nih.gov/pubmed/21373268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.10-75
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