Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome

The inflammasome is a large, multiprotein complex that consists of a nucleotide-binding oligomerization domain-like receptor (NLR), an apoptosis-associated speck-like protein containing a caspase recruitment domain, and pro-caspase-1. Activation of the inflammasome results in cleavage of pro-caspase...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Otani, Koji, Watanabe, Toshio, Shimada, Sunao, Takeda, Shogo, Itani, Shigehiro, Higashimori, Akira, Nadatani, Yuji, Nagami, Yasuaki, Tanaka, Fumio, Kamata, Noriko, Yamagami, Hirokazu, Tanigawa, Tetsuya, Shiba, Masatsugu, Tominaga, Kazunari, Fujiwara, Yasuhiro, Arakawa, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009328/
https://ncbi.nlm.nih.gov/pubmed/27585971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32587
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