NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis

The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We investigated roles of the NLRP3 inflammasome in the pathogenesis of ulcerative colitis (UC). After induction of oxazolone-induced colitis, a mouse UC model, colonic tissues were assayed for inflammatory mediators. Hi...

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Publicat a:Sci Rep
Autors principals: Itani, Shigehiro, Watanabe, Toshio, Nadatani, Yuji, Sugimura, Naoki, Shimada, Sunao, Takeda, Shogo, Otani, Koji, Hosomi, Shuhei, Nagami, Yasuaki, Tanaka, Fumio, Kamata, Noriko, Yamagami, Hirokazu, Tanigawa, Tetsuya, Shiba, Masatsugu, Tominaga, Kazunari, Fujiwara, Yasuhiro, Arakawa, Tetsuo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155456/
https://ncbi.nlm.nih.gov/pubmed/27966619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39075
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