A role for human Dicer in pre-RISC loading of siRNAs

RNA interference is a powerful mechanism for sequence-specific inhibition of gene expression. It is widely known that small interfering RNAs (siRNAs) targeting the same region of a target-messenger RNA can have widely different efficacies. In efforts to better understand the siRNA features that infl...

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Bibliographic Details
Main Authors: Sakurai, Kumi, Amarzguioui, Mohammed, Kim, Dong-Ho, Alluin, Jessica, Heale, Bret, Song, Min-sun, Gatignol, Anne, Behlke, Mark A., Rossi, John J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045585/
https://ncbi.nlm.nih.gov/pubmed/20972213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq846
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