Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

Despite the great potential of RNAi, ectopic expression of shRNA or siRNAs holds the inherent risk of competition for critical RNAi components, thus altering the regulatory functions of some cellular microRNAs. In addition, specific siRNA sequences can potentially hinder incorporation of other siRNA...

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Main Authors: Castanotto, Daniela, Sakurai, Kumi, Lingeman, Robert, Li, Haitang, Shively, Louise, Aagaard, Lars, Soifer, Harris, Gatignol, Anne, Riggs, Arthur, Rossi, John J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2007
主題:
RNA
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976469/
https://ncbi.nlm.nih.gov/pubmed/17660190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm543
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