Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

Despite the great potential of RNAi, ectopic expression of shRNA or siRNAs holds the inherent risk of competition for critical RNAi components, thus altering the regulatory functions of some cellular microRNAs. In addition, specific siRNA sequences can potentially hinder incorporation of other siRNA...

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Bibliographic Details
Main Authors: Castanotto, Daniela, Sakurai, Kumi, Lingeman, Robert, Li, Haitang, Shively, Louise, Aagaard, Lars, Soifer, Harris, Gatignol, Anne, Riggs, Arthur, Rossi, John J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976469/
https://ncbi.nlm.nih.gov/pubmed/17660190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm543
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