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Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC
Despite the great potential of RNAi, ectopic expression of shRNA or siRNAs holds the inherent risk of competition for critical RNAi components, thus altering the regulatory functions of some cellular microRNAs. In addition, specific siRNA sequences can potentially hinder incorporation of other siRNA...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976469/ https://ncbi.nlm.nih.gov/pubmed/17660190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm543 |
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