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Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants
The canonical exogenous trigger of RNA interference (RNAi) in mammals is small interfering RNA (siRNA). One promising application of RNAi is siRNA-based therapeutics, and therefore the optimization of siRNA efficacy is an important consideration. To reduce unfavorable properties of canonical 21mer s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3695504/ https://ncbi.nlm.nih.gov/pubmed/23620279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt200 |
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