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Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA

Upon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of siRNAs as potential new drugs, there are obstacles still to be overcome, including off-target effects and immune stimulation...

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Bibliografische gegevens
Gepubliceerd in:Asian J Pharm Sci
Hoofdauteurs: Raja, Maria Abdul Ghafoor, Katas, Haliza, Amjad, Muhammad Wahab
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Shenyang Pharmaceutical University 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032099/
https://ncbi.nlm.nih.gov/pubmed/32104477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2018.12.005
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