Structure Determination of Glycogen Synthase Kinase-3 from Leishmania major and Comparative Inhibitor Structure-Activity Relationships with Trypanosoma brucei GSK-3

Glycogen synthase kinase-3 (GSK-3) is a drug target under intense investigation in pharmaceutical companies and constitutes an attractive piggyback target for eukaryotic pathogens. Two different GSKs are found in trypanosomatids, one about 150 residues shorter than the other. GSK-3 short (GeneDB: Tb...

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Autores principales: Ojo, Kayode K., Arakaki, Tracy L., Napuli, Alberto J., Inampudi, Krishna K., Keyloun, Katelyn R., Zhang, Li, Hol, Wim G.J., Verlinde, Christophe L.M.J., Merritt, Ethan A., Van Voorhis, Wesley C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045540/
https://ncbi.nlm.nih.gov/pubmed/21195115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2010.12.009
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