Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Development of a safe, effective, and inexpensive therapy for African trypanosomiasis is an urgent priority. In this study, we evaluated the validity of Trypanosoma brucei glycogen synthase kinase 3 (GSK-3) as a potential drug target. Interference with the RNA of either of two GSK-3 homologues in bl...

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Hauptverfasser: Ojo, Kayode K., Gillespie, J. Robert, Riechers, Aaron J., Napuli, Alberto J., Verlinde, Christophe L. M. J., Buckner, Frederick S., Gelb, Michael H., Domostoj, Mathias M., Wells, Susan J., Scheer, Alexander, Wells, Timothy N. C., Van Voorhis, Wesley C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565902/
https://ncbi.nlm.nih.gov/pubmed/18644955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00364-08
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