Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Development of a safe, effective, and inexpensive therapy for African trypanosomiasis is an urgent priority. In this study, we evaluated the validity of Trypanosoma brucei glycogen synthase kinase 3 (GSK-3) as a potential drug target. Interference with the RNA of either of two GSK-3 homologues in bl...

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Bibliographic Details
Main Authors: Ojo, Kayode K., Gillespie, J. Robert, Riechers, Aaron J., Napuli, Alberto J., Verlinde, Christophe L. M. J., Buckner, Frederick S., Gelb, Michael H., Domostoj, Mathias M., Wells, Susan J., Scheer, Alexander, Wells, Timothy N. C., Van Voorhis, Wesley C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565902/
https://ncbi.nlm.nih.gov/pubmed/18644955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00364-08
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