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Inhibition of Osteoclast Formation and Function by Bicarbonate: Role of Soluble Adenylyl Cyclase

High [HCO(3)(−)] inhibits and low [HCO(3)(−)] stimulates bone resorption which mediates part of the effect of chronic acidosis or acid feeding on bone. Soluble adenylyl cyclase (sAC) is a bicarbonate sensor that can potentially mediate the effect of bicarbonate on osteoclasts. Osteoclasts were incub...

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Detalhes bibliográficos
Main Authors: Geng, Weidong, Hill, Kathy, Zerwekh, Joseph, Kohler, Thomas, Müller, Ralph, Moe, Orson W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044925/
https://ncbi.nlm.nih.gov/pubmed/19360717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21767
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