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Inhibition of Osteoclast Formation and Function by Bicarbonate: Role of Soluble Adenylyl Cyclase
High [HCO(3)(−)] inhibits and low [HCO(3)(−)] stimulates bone resorption which mediates part of the effect of chronic acidosis or acid feeding on bone. Soluble adenylyl cyclase (sAC) is a bicarbonate sensor that can potentially mediate the effect of bicarbonate on osteoclasts. Osteoclasts were incub...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044925/ https://ncbi.nlm.nih.gov/pubmed/19360717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21767 |
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