Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis

pH homeostasis is essential for life, yet it remains unclear how animals sense their systemic acid/base (A/B) status. Soluble adenylyl cyclase (sAC) is an evolutionary conserved signaling enzyme that produces the second messenger cAMP in response to bicarbonate ions (HCO(3)(−)). We cloned the sAC or...

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Bibliographic Details
Main Authors: Tresguerres, Martin, Parks, Scott K., Salazar, Eric, Levin, Lonny R., Goss, Greg G., Buck, Jochen
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806762/
https://ncbi.nlm.nih.gov/pubmed/20018667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911790107
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