Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture

We developed and validated a semi-automated LC/LC-MS/MS assay for the quantification of imatinib in human whole blood and leukemia cells. After protein precipitation, samples were injected into the HPLC system and trapped onto the enrichment column (flow 5 mL/min); extracts were back-flushed onto th...

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Detalhes bibliográficos
Main Authors: Klawitter, Jelena, Zhang, Yan Ling, Klawitter, Jost, Anderson, Nora, Serkova, Natalie J., Christians, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044679/
https://ncbi.nlm.nih.gov/pubmed/19517424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.1247
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