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Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation
One of the major hallmarks of Parkinson disease is aggregation of the protein α-synuclein (αSN). Aggregate cytotoxicity has been linked to an oligomeric species formed at early stages in the aggregation process. Here we follow the fibrillation process of αSN in solution over time using small angle X...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044375/ https://ncbi.nlm.nih.gov/pubmed/21300904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013225108 |
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