The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner

Changes of the microtubule-associated protein tau are central in Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). However, the functional consequence of the FTDP-17 tau mutation R406W, which causes a tauopathy clinically resembling AD, is not...

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Detalhes bibliográficos
Main Authors: Gauthier-Kemper, Anne, Weissmann, Carina, Golovyashkina, Nataliya, Sebö-Lemke, Zsofia, Drewes, Gerard, Gerke, Volker, Heinisch, Jürgen J., Brandt, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044115/
https://ncbi.nlm.nih.gov/pubmed/21339331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007161
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