NKG2D initiates caspase-mediated CD3ζ degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease

Deficiencies of the T cell and NK cell CD3ζ signaling adapter protein in cancer and autoimmune disease patients are well documented but mechanistic explanations are fragmentary. The stimulatory NKG2D receptor on T cells and NK cells mediates tumor immunity but can also promote local and systemic imm...

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Bibliografiset tiedot
Päätekijät: Hanaoka, Nobuyoshi, Jabri, Bana, Dai, Zhenpeng, Ciszewski, Cezary, Stevens, Anne M., Yee, Cassian, Nakakuma, Hideki, Spies, Thomas, Groh, Veronika
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044081/
https://ncbi.nlm.nih.gov/pubmed/20926796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002092
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