Cytosolic PLA(2) is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

IL-15 and NKG2D promote autoimmunity and celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events underlying these functional properties remain unclear. Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tang, Fangming, Chen, Zhangguo, Ciszewski, Cezary, Setty, Mala, Solus, Jason, Tretiakova, Maria, Ebert, Ellen, Han, Jin, Lin, Anning, Guandalini, Stefano, Groh, Veronika, Spies, Thomas, Green, Peter, Jabri, Bana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699120/
https://ncbi.nlm.nih.gov/pubmed/19237603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071887
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