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NKG2D initiates caspase-mediated CD3ζ degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
Deficiencies of the T cell and NK cell CD3ζ signaling adapter protein in cancer and autoimmune disease patients are well documented but mechanistic explanations are fragmentary. The stimulatory NKG2D receptor on T cells and NK cells mediates tumor immunity but can also promote local and systemic imm...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044081/ https://ncbi.nlm.nih.gov/pubmed/20926796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002092 |
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