Phorbol ester and endothelin-1 alter functional expression of Na(+)/Ca(2+) exchange, K(+), and Ca(2+) currents in cultured neonatal rat myocytes

Endothelin-1 (ET-1) and activation of protein kinase C (PKC) have been implicated in alterations of myocyte function in cardiac hypertrophy and heart failure. Changes in cellular Ca(2+) handling and electrophysiological properties also occur in these states and may contribute to mechanical dysfuncti...

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Detalhes bibliográficos
Main Authors: Puglisi, José L., Yuan, Weilong, Timofeyev, Valeriy, Myers, Richard E., Chiamvimonvat, Nipavan, Samarel, Allen M., Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044063/
https://ncbi.nlm.nih.gov/pubmed/21131481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00388.2010
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