Effects of mitochondrial uncoupling on Ca(2+) signaling during excitation-contraction coupling in atrial myocytes

Mitochondria play an important role in intracellular Ca(2+) concentration ([Ca(2+)](i)) regulation in the heart. We studied sarcoplasmic reticulum (SR) Ca(2+) release in cat atrial myocytes during depolarization of mitochondrial membrane potential (ΔΨ(m)) induced by the protonophore FCCP. FCCP cause...

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Bibliographic Details
Main Authors: Zima, Aleksey V., Pabbidi, Malikarjuna R., Lipsius, Stephen L., Blatter, Lothar A.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Cardiac Excitation and Contraction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625900/
https://ncbi.nlm.nih.gov/pubmed/23376829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00932.2012
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