Evaluation of mRNA by Q-RTPCR and Protein Expression by AQUA of the M2 Subunit of Ribonucleotide Reductase (RRM2) in Human Tumors

PURPOSE: The purpose of this study was to evaluate baseline RRM2 protein and gene expression in tumors of patients receiving 3-AP. EXPERIMENTAL DESIGN: Tumor blocks from patients enrolled in phase I and II clinical studies using 3-AP, were evaluated for RRM2 gene and protein expression by quantitati...

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Autori principali: Kolesar, Jill, Huang, Wei, Eickhoff, Jens, Hahn, Kristine, Alberti, Dona, Attia, Steve, Schelman, William, Holen, Kyle, Traynor, Anne, Ivy, Percy, Wilding, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043989/
https://ncbi.nlm.nih.gov/pubmed/18941749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0845-0
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