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Soluble adenylyl cyclase mediates bicarbonate-dependent corneal endothelial cell protection

Cyclic AMP produced from membrane receptor complex bound adenylyl cyclases is protective in corneal endothelial cells (CEC). CEC also express soluble adenylyl cyclase (sAC), which is localized throughout the cytoplasm. When activated by HCO(3)(−), cAMP concentration ([cAMP]) increases by ∼50%. Here...

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Bibliografiske detaljer
Main Authors: Li, Shimin, Allen, Kah Tan, Bonanno, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043628/
https://ncbi.nlm.nih.gov/pubmed/21123735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00314.2010
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