[HCO(3)(-)]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells

BACKGROUND: Bicarbonate activated Soluble Adenylyl Cyclase (sAC) is a unique cytoplasmic and nuclear signaling mechanism for the generation of cAMP. HCO(3)(- )activates sAC in bovine corneal endothelial cells (BCECs), increasing [cAMP] and stimulating PKA, leading to phosphorylation of the cystic fi...

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Detaylı Bibliyografya
Asıl Yazarlar: Sun, Xing Cai, Cui, Miao, Bonanno, Joseph A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2004
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC411047/
https://ncbi.nlm.nih.gov/pubmed/15117409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6793-4-8
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